Epigenetic Biomarkers for Alzheimer's Disease

Chinese University of Hong Kong250 enrolled

Overview

Alzheimer's disease (AD) is a neurodegenerative disorder with no know cure. The pathogenesis of late onset AD (LOAD) is complex and multifactorial in nature, with multiple susceptibility genes and environmental factors at interplay. The objective of this study is to improve our understanding of the risk factors of LOAD by conducting an epigenome wide study within patients of LOAD contrasted against their cognitively normal siblings.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Alzheimer Disease

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Sufficient Cantonese competency for cognitive test * Written informed consent given * Have at least one gender-matched cognitively normal sibling Exclusion Criteria: * Subjects who refuse blood taking procedure * Do not have a reliable family/caregiver informant (personal contact at least once a month)

Locations (1)

The Chinese University of Hong Kong

Hong Kong, Hong Kong

Outcomes

Primary Outcomes

DNA methylation

Time frame: 5 years

RNA-seq microbiome

Time frame: 5 years

Alzheimer's disease Assessment Scale-cognitive subscale (Adas-Cog)

Time frame: 5 years

Data from ClinicalTrials.gov

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