In this study, researchers wanted to learn more about the effect of Aspirin taken as low dose (75 - 300 mg) in preventing stomach, colorectal and esophagus cancer. The researchers were interested in the effect by duration of aspirin use and the effect on the time since aspirin intake has been stopped in preventing stomach, colorectal and esophagus cancer. In addition, the study also looked into the time patients survived after being diagnosed (survival rate) with cancer and number of cancer patients who died (case fatality rate). The study was based on an electronic database managed by the Health Authority in Hong Kong containing anonymized clinical information of patients living in Hong Kong.
Study Type
OBSERVATIONAL
Enrollment
99,999
Follow clinical administration
University of Hong Kong
Hong Kong, Hong Kong
Incidence rate ratio of colorectal cancer among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
Ratio of incidence (per 10,000 person years) among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
Time frame: Retrospective analysis between 1st January 2004 and 31st December 2008
Incidence rate ratio of gastric cancer among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
Ratio of incidence (per 10,000 person years) among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
Time frame: Retrospective analysis between 1st January 2004 and 31st December 2008
Incidence rate ratio of esophageal cancer among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
Ratio of incidence (per 10,000 person years) among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
Time frame: Retrospective analysis between 1st January 2004 and 31st December 2008
Duration of aspirin use
Minimum duration of aspirin use to confer the protective effects in preventing colorectal, gastric and esophageal cancer
Time frame: Retrospective analysis between 1st January 2004 and 31st December 2008
Risk of colorectal, gastric and esophageal cancer after discontinuation of aspirin use
Logistic regression will be conducted based on nested case-control study with stratification on the recency of exposure with current use, past use, and distant use of aspirin.
Time frame: Retrospective analysis between 1st January 2004 and 31st December 2008
Case-fatality and survival rate
For colorectal cancer, gastric or oesophageal
Time frame: Retrospective analysis between 1st January 2004 and 31st December 2008
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