Causes and Consequences of Primary Ovarian Insufficiency

Haukeland University Hospital100 enrolled

Overview

100 women with primary ovarian insufficiency will be included for extensive diagnostic workup to improve diagnostic precision by extended autoantibody screening and genetic and toxicological testing.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Primary Ovarian Insufficiency Premature Menopause

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria:Women 40 years or younger, more than 4 months amenorrhea, more than 2 FSH measurements in menopausal range (drawn at least 2 months apart), ability to provide informed concent - Exclusion Criteria:History of oophorectomy, chemotherapy or radiation \-

Locations (1)

HaukelandUH

Bergen, Norway

RECRUITING

Outcomes

Primary Outcomes

Autoimmune

Prevalence of primary ovarian insufficiency (POI) with autoimmune etiology based on positive autoantibodies toward steroidogenic cells

Time frame: one day

Genetic

Prevalence of POI with genetic etiology defined by detection of genetic defects in a NGS panel

Time frame: one day

Endocrine disrupting chemicals

Characterize the cohort of women with POI, including testing for environmental factors

Time frame: one day

Secondary Outcomes

Phenotype description

Describe phenotypical characteristics including menstrual characteristics, hormone profile, BMD

Time frame: one day

Central Contacts

Eystein Husebye, prof

CONTACT

+4755975000 eyhu@helse-bergen.no

Data from ClinicalTrials.gov

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