Correlates of Left Ventricular Global Longitudinal Strain and Surgical Intervention on Myocardial Bridges

ITAB - Institute for Advanced Biomedical Technologies10 enrolled

Overview

To examine the changes in left ventricular (LV) global longitudinal strain (GLS), using two-dimensional speckle tracking analysis, after left anterior descending (LAD) unroofing, in myocardial bridges (MBs) refractory to optimal medical therapy (OMT).

The present study is enrolling all the MBs-patients who underwent angina surgical relief or medical treatment at the "Ospedali Riuniti" of Ancona, Italy, and the "University Hospital" of Chieti, Italy. All the participants will be examined utilizing echocardiography before and after the treatment. The two-dimensional speckle-tracking analysis will be performed with an off-line dedicated software from the apical 4-chambers-view. All the unroofing procedures will be performed under cardiopulmonary bypass.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Myocardial Bridge of Coronary Artery

Interventions

Surgical unroofing of muscle-briged coronary arteryPROCEDURE

Medical therapy with beta-blockers or calcium-channels blockers

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Myocardial bridge of the anterior descending left coronary artery Exclusion Criteria: * Poor echocardiographic imaging quality

Locations (1)

Ospedali Riuniti

Ancona, Italy

Outcomes

Primary Outcomes

Improvement of myocardial function and contractility

The increment of global longitudinal strain analysis, from pre treatment values, as assessed by speckle-traking echocardiography

Time frame: 1 to 6 month after the procedure/treatment optimizzation

Secondary Outcomes

Angina relief after surgical treatment

Defined as the reduction of CCS-Angina Scale, assessed by physicians, from grade I (ordinary physical activity does not cause angina, such as walking and climbing stairs) to grade IV (inability to carry on any physical activity without discomfort, anginal syndrome may be present at rest). The scale comprises 4 degrees in increasing order of angina severity.

Time frame: 1-month

Improvement in quality of life

Defined as the score increment, from 0 to 100 of the SAQ-7 questionnaire. The SAQ quantifies patients' physical limitations caused by angina, the frequency of and recent changes in their symptomstheir satisfaction with treatment, and the degree to which they perceive their disease to affect their quality of life. The questionnaire provides 7 different items with 6 different multiple choices. Each scale is transformed to a score of 0 to 100, where higher scores indicate better function (eg, less physical limitation, less angina, and better quality of life).

Time frame: 1-month

Data from ClinicalTrials.gov

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