Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery

Hvidovre University Hospital36 enrolled

Overview

The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Glucose Metabolism Disorders Obesity Sleeve Gastrectomy Gastric Bypass Gut Hormones

Interventions

Liquid mealOTHER

Four-hour liquid mixed meal test

Solid mealOTHER

Four-hour solid mixed meal test

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years * RYGB or SG operation \> 12 months prior to inclusion * Weight stable (± 3 kg during the last month) * HbA1c \< 48 mmol/mol before surgery, and no history of diabetes * HbA1c \< 48 mmol/mol and fasting plasma glucose \< 6.1 mmol/l at inclusion Exclusion Criteria: * Thyrotoxicosis or inadequately treated hypothyreosis * Hemoglobin \< 6.5 mmol/l at inclusion * Pregnancy or breast feeding * Medication affecting the planned examinations

Locations (1)

Department of Endocrinology, Hvidovre University Hospital

Copenhagen, Hvidovre, Denmark

Outcomes

Primary Outcomes

GLP-1 response

GLP-1 response after a liquid meal test compared to a solid meal test

Time frame: 240 minutes

Secondary Outcomes

Difference in gut hormone response after bariatric surgery

Time frame: 240 minutes

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.