In this randomized control trial the patients with acute appendicitis will be divided in three groups according to the management of the appendiceal stump(Endostapler, Endoloop or Endoclip). Pre-, peri- and postoperative data will be analysed.
Acute appendicitis is the most common indication for intraabdominal emergency surgery, and appendectomy is one of the most commonly performed procedures in abdominal surgery. Today laparoscopic appendectomy (LA) has the status of a ''Gold Standard'' treatment, and it is accepted as the treatment of choice for acute appendicitis.There are several ways of closing the appendiceal stump.An inadequate closure of the appendiceal stump can lead to morbidity of operated patients. The aim of this study is to assess the efficiency of different closure techniques by focusing on the intraoperative and postoperative complications.The patients will be divided into three groups based on the technique used for appendiceal stump closure, whether it is Endoloop, Endostapler or Endoclip. In the patients included in the study the investigators will analyse demographic data, peroperative laboratory values, clinical data and treatment outcomes. Also, the histopathological findings of the specimens and perioperative and postoperative complications will be analysed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
300
In all patients, laparoscopic appendectomy is performed, only difference is the way of managing appendiceal stump
UH Dubrava
Zagreb, Croatia
Operative and postoperative complications
Number of all complications will be presented in total numbers.
Time frame: Seven postoperative days
Operative and postoperative complications
Complications will be presented as a percentage of the all operated patients.
Time frame: Seven postoperative days
Value levels of leukocytes
Whit blood cells count
Time frame: Before surgery
Duration of symptoms
Duration of symptoms will be measured in hours.
Time frame: Before surgery
Height
Meters
Time frame: Before surgery
Weight
Kilograms
Time frame: Before surgery
C-reactive protein
Milligrams/liter
Time frame: Before surgery
Neutrophiles
Neutrophile count
Time frame: Before surgery
Body mass index
Kilograms/meter square
Time frame: Before surgery
Body temperature
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Body temperature will be measured in degrees celsius.
Time frame: Before surgery
Length of the operations
Length of the operations will be presented in minutes.
Time frame: During operation
Closure of the appendiceal stump using Endoloop
Number of patients in which this technique was performed.
Time frame: During operation
Closure of the appendiceal stump using Endoloop
Percentage of the all operated patients in which this technique was used.
Time frame: During operation
Closure of the appendiceal stump using Endostapler
Number of patients in which this technique was performed
Time frame: During operation
Closure of the appendiceal stump using Endostapler
Percentage of the all operated patients in which this technique was used.
Time frame: During operation
Closure of the appendiceal stump using Endoclip
Number of patients in which this technique was performed
Time frame: During operation
Closure of the appendiceal stump using Endoclip
Percentage of the all operated patients in which this technique was used.
Time frame: During operation
Number of reoperated patients
Presented in total numbers
Time frame: Seven days
Hospital stay
Length of the hospital stay will be presented in days.
Time frame: Seven days
Histopathological findings
Histopathological findings will be graduated in 3 grades - phlegmonous,gangrenous and perforated.
Time frame: Seven days
Percentage of reoperated patients
Presented in percentages
Time frame: Seven days