The purpose of this study is to determine if a 6-week period of ketone salt supplementation affects physiological, emotional, cognitive, and/or behavioral health markers in individuals with PTSD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
24
6-week supplementation with ketone salts
Placebo was taken for 6-weeks and was calorie and flavor matched to the ketone salt supplement.
Augusta University
Augusta, Georgia, United States
RECRUITINGChange in Comprehensive Metabolic Panel
Blood health marker
Time frame: Pre- and Post- 6-week supplemental period
Change in Complete Blood Count
Blood health marker
Time frame: Pre- and Post- 6-week supplemental period
Change in Cognitive Performance
ANAM test battery
Time frame: Pre- and Post- 6-week supplemental period
Change in Blood Pressure
Cardiovascular health measure
Time frame: Pre- and Post- 6-week supplemental period
Change in Urinalysis
Health measure
Time frame: Pre- and Post- 6-week supplemental period
Change in Insomnia
Insomnia Severity Questionnaire
Time frame: Pre- and Post- 6-week supplemental period
Change in Emotional Health
Title: 12-Item Grit Scale; Construct: measures trait-level perserverance and passion for long-term goals; the scale for each question includes the following answers to check: Very much like me, mostly like me, somewhat like me, not much like me, not like me at all; Scoring: for questions 1, 4, 6, 9, 10, and 12 the following answers receive the associated number as a score: Very much like me (5), Mostly like me (4), Somewhat like me (3), Not much like me (2), Not like me at all (1). And questions 2, 3, 5, 7, 8, and 11 receive the following points for the checked answers: Very much like me (1 points), Mostly like me (2 points), Somewhat like me (3 points), Not much like me (4 points), Not like me at all (5 points). Add up all the points and divide by 12. The maximum score on this scale is 5 (extremely gritty) and the lowest score is 1 (not at all gritty).
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Pre- and Post- 6-week supplemental period
Change in Emotional Health
Title: Visual Analog Scales; Construct: measures the intensity or frequency of various symptoms; the scale is numerical with numbers from 0 to 10 lined horizontally and 0 indicates no symptom at all, 5 indicated neutral, and 10 indicates the highest feeling of the symptom. Symptoms asked included Hunger (0=not hungry at all, 10= very hungry), Satiety (0=don't feel full at all, 10=very full) , Mood (0= feel very down, 10= feel wonderful), Energy (0= very tired, 10=very energized), Focus (0= very distracted, 10=very focused), Alertness (0=non-coherent, 10= very aware of my surroundings)
Time frame: Pre- and Post- 6-week supplemental period
Change in Emotional Health
Mood Disorder Questionnaire
Time frame: Pre- and Post- 6-week supplemental period
Change in alcohol use
Alcohol Use Disorders Questionnaire
Time frame: Pre- and Post- 6-week supplemental period
Change in PTSD
PTSD Checklist for DSM-5
Time frame: Pre- and Post- 6-week supplemental period
Change in PTSD
Patient Health Questionnaire-9
Time frame: Pre- and Post- 6-week supplemental period
Change in pain
Pain Outcomes Questionnaire
Time frame: Pre- and Post- 6-week supplemental period
Change in PTSD
Adverse Childhood Experience Questionnaire
Time frame: Pre- and Post- 6-week supplemental period