Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis

First People's Hospital of Chenzhou20 enrolled

Overview

The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）

Continous renal replacement therapy （CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .In clinical patients ，continous venovenous hemofoiltration （CVVH）is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index，increasing cardiac index and regulating immune dysfuntion .

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Intensive Care Unit

Interventions

continous venovenous hemofiltraionPROCEDURE

CVVH

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Adult septic patients undergoing CRRT Exclusion Criteria: 1. Missing vists 2. transplatation 3. cancer 4. aquired immunodeficiency syndrome

Locations (1)

The First Hospital of Chenzhou

Chenzhou, Hunan, China

Outcomes

Primary Outcomes

Change of mtDNA concentration in plasma

The specimens in the prefilter and postfilter blood as well as in the ultrafiltrate were obtained at the beginning of CRRT (T0) and 6 h (T6h), 12 h (T12h) after the setup of CVVH.

Time frame: befor,6hours, 12hours, after CVVH treatment

Data from ClinicalTrials.gov

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