Efficacy and Safety of TISSEEL Lyo Compared to Manual Compression as an Adjunct to Haemostasis

Inclusion Criteria: * Signed informed consent; * Male or female ≥ 18 ages; * Patients undergoing primary vascular surgery (i.e., conduit placement with an ePTFE graft), including the following: 1. Arterio-arterial-bypass; * Ilio-femoral bypass; * Femoro-femoral bypass; * Ilio-popliteal bypass; * Femoro-popliteal bypass; * Femoro-tibial vessel bypass 2. Arteriovenous shunting for dialysis access in the upper or lower extremity; Intraoperative inclusion criterion: * Suture line bleeding eligible for study treatment is present after surgical hemostasis. Exclusion Criteria: * Concurrent participation in another clinical study treatment with another investigational drug or device within last 30 days; * Other vascular procedures during the same surgical session; * Arterio-arterial bypasses with more than two anastomoses; * Haemoglobin \<9.0 g/dL at screening; * Pregnant or lactating women; * Congenital or acquired coagulation disorders; * Prior kidney transplantation; * Heparin-induced thrombocytopenia; * Known prior exposure to aprotinin within the last 12 months; * Known hypersensitivity to aprotinin, heparin, blood products or other components of the investigational product; * Unwilling to receive blood products. * Known severe congenital or acquired immunodeficiency; * Prior radiation therapy to the operating field; * Severe local inflammation at the operating field; * Positive results of any of the following the blood tests: HIV, syphilis, hepatitis B, hepatitis C. * Emergency surgery. * Alcohol or drug abuse. Intraoperative exclusion criteria: * Major intraoperative complications that required resuscitation or deviation from the planned surgical procedure; * Intraoperative change in planned surgical procedure, which resulted in patient no longer meeting preoperative inclusion criteria or having preoperative exclusion criteria.