The aim of this study is to investigate the effect of barberry consumption on systolic and diastolic blood pressure, serum lipids, and inflammatory status. The study will involve cases having elevated BP (129/ \< 85) and known hypertensive patients on medical treatment. Seventy people will be randomized into two groups, including intervention (barberry) or placebo groups. Before and after of 8 week intervention, 24-hour ambulatory blood pressure monitoring will be done and fasting venous blood sample will be taken to measure plasma lipids. In addition, 24-hour urine will be collected to measure its sodium content and estimate sodium intake.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
78
10 grams of barberry powder will be consumed daily for 8 weeks.
Placebo powder
Rajaei Cardiovascular, Medical & Research Center
Tehran, Iran
blood pressure
mean of systolic and diastolic blood pressure of participants measured by ambulatory 24 hour blood pressure monitoring
Time frame: at 8 weeks
lipid profile
plasma TC, LDL-C, HDL-C, TG
Time frame: at 8 weeks
plasma NOx
concentration of nitrite and nitrate in plasma
Time frame: at 8 weeks
Inflammatory cytokine
Plasma Interleukin-6
Time frame: at 8 weeks
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