The aim of this study is to identify in hospitalized patients, the risk factors associated with the digestive colonisation by emergent extensively drug-resistant bacteria (eXDR), to optimize their detection and the medical care for carriers these patients
CODBAHRE is a french, regional study, involving 9 centers. Recruitment will take place in all the departments of the centers involved under the supervision of the Infection Control Team. All patients hospitalized more than 24 hours, on a given day are eligible for the protocol, except the patients unable to answer the questionnaire. After collecting the non-opposition of the patient, patients will be screened by rectal swab and a questionnaire will be completed. Each sample will be analyzed to detect eXDR carrying patients. The carrying patients will be followed during 6 months to estimate the proportion of the population which developped a bacterial infection. This information will be collected by a retrospective telephone survey of carrying patients.
Study Type
OBSERVATIONAL
Enrollment
2,396
HEGP
Paris, France
Risk factors
Identification of risk factors for digestive colonisation by highly resistant bacteria Lifestyle questionnaire: environment, diet, medical history and result of the rectal swab
Time frame: at inclusion
Prevalence of multidrug-resistant bacteria will be determined by the number of patients who have been detected at least one multidrug-resistant bacteria referred to the number of patients sampled
Number of patient carrying a Multidrug-resistant bacteria in Ile de France
Time frame: 1 day
Prevalence of co-carrying patients of eXDR and ESBL will be determined by the number of patients who carrying eXDR and ESBL referred to the number of patients sampled
Estimate the prevalence of "co-carrying patients of eXDR and ESBL in the Ile de France
Time frame: 1 day
Prevalence will be determined by the number of patients who carrying at least one Multidrug-resistant bacteria referred to the number of patients sampled
Establish whether there are significant differences between hospital associated with the recruitment of these institutions.
Time frame: 1 day
Proportion of patients carrying "eXDR" who will develop an infection with the same germ referred to the number of eXDR carriers
Estimate the proportion of patients colonized by a "eXDR" who will develop an infection with the same germ.
Time frame: 6 months
Cross-transmission rate of eXDR
Number of cross transmissions during the study by comparing the eXDR bacteria genotypes in the same unit
Time frame: 1 day
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Description of the association between strains (RAPD, infrared Biotyper, genome sequencing).
Identify possible links between strains
Time frame: 16 months
Description of resistance and virulence characteristics between strains (RAPD, infrared Biotyper, genome sequencing).
Characterize the resistance and virulence factors of certain strains.
Time frame: 16 months
Comparison of the frequency of positive presence of eXDR bacteria obtained between culture technic and molecular biology technic
Comparison culture vs molecular biology technics.
Time frame: 16 months