Study of what the body does to drug BMS-986165 when it is taken together with pyrimethamine
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
16
Oral administration of tablet BMS- 986165
Oral administration of Pyrimethamine in combination with BMS-986185
PRA Health Sciences - Salt Lake
Salt Lake City, Utah, United States
Maximum observed serum comcentration (Cmax)
Time frame: Day 1, Day 5
Area under the concentration-time curve from time zero extrapolated to AUC(INF)
Time frame: Day 1, Day 5
Incidences of Adverse Events (AE's)
Time frame: Approximetly 20 days
Time of maximum observed concentration (Tmax)
Time frame: Approxmiately 20 days
Half- life time (T-Half)
Time frame: Day 1, Day 5
Apparent oral clearance (CL/F)
Time frame: Day 5
Apparent volume of distribution at terminal phase (Vz/F)
Time frame: Day 5
Ratio of metabolite AUC(0-T) to parent AUC(0-T) corrected for Molecular weight MRAUC(0-T)
Time frame: Day 5
Ratio of metabolite AUC(INF) to parent AUC(INF) corrected for Moecular weight MRAUC(INF)
Time frame: Day 5
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