The rising number of patients with chest pain without myocardial infarction has made accurate diagnosis important. Unnecessary invasive coronary angiographies are increasingly prevalent. These are both costly and lead to rare but serious adverse events. Recent studies suggest cardiac Troponin I is more cardiac specific than cardiac Troponin T. In this study we will investigate whether using cardiac Troponin I lead to fewer unnecessary procedures in clinical practice (i.e. invasive coronary angiography and non-invasive tests)
Study Type
OBSERVATIONAL
Enrollment
300
Does the use of troponin T or I increase the number of patients referred to coronary angiography
Bispebjerg Hospital
Bispebjerg, Copenhagen, Denmark
RECRUITINGHerlev-Gentofte Hospital
Herlev, Denmark
RECRUITINGSpecificity for MI
The difference in specificity of cardiac Troponin and I in detecting patients with significant CAD. The specificity will be defined as the proportion of patients with no significant CAD on ICA correctly identified as low-risk patients and not referred to ICA upon the review by the senior cardiologists
Time frame: 0
Cost-effectiveness
The cost-effectiveness of using cardiac Troponin T compared to cardiac Troponin I. This will be defined by the number of patients sent to ICA and the associated costs of this.
Time frame: 0
Sensitivity for MI
A safety outcome of difference in sensitivity of cardiac Troponin T and cardiac Troponin I in the detection of patients with significant coronary artery disease. The sensitivity is defined as the proportion of patients with significant coronary artery disease that were referred to ICA upon review by the senior cardiologists
Time frame: 0
Elevated troponin without CAD
The difference in the proportion of patients with elevated cardiac Troponin T or cardiac Troponin I above the 99th percentile with no significant CAD on ICA
Time frame: 0
Number of MIs
The difference in the number of patients diagnosed with MI for each cardiac Troponin
Time frame: 0
PPV and NPV
The difference in positive predictive value and negative predictive value of each cardiac Troponin
Time frame: 0
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