The purpose of this study is to evaluate the satiating effects of a meat derivative and a satiating compound on overweight subjects (BMI ≥25 and \<30 kg / m2).
A randomized, parallel, controlled and double-blind pilot study with 3 study arms is being performed to evaluate the satiating properties of a meat derivate and a satiating compound in a group of healthy overweight subjects. The investigators included 20 participants between 18 and 65 years (BMI ≥25 and \<30 kg / m2). All volunteers will be randomized into 3 study groups, and participants will receive the 2 study products during the 3 experimental phases.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
19
Subjects will consume 60 g of meat derivative placebo in a brunch type meal with 25 g of the satiating compound placebo diluted in water
Subjects will consume 60 g of meat derivative placebo in a brunch type meal with 25 g of the satiating compound diluted in water
Subjects will consume 60 g of the experimental meat derivative in a brunch type meal with 25 g of satiating compound placebo diluted in water
Institute for Health Research IdiPAZ
Madrid, Spain
Change from Baseline Satiety Hunger Assessment
Visual Analogue Scale (VAS). 100 mm horizontal line anchored at each end with the extremes of the subjective feeling to be quantified. Subjects are instructed to rate the sensation being experienced according to how they define the line. e.g., "not at all hungry" (0mm) and "as hungry as I have ever felt" (100mm). Multiple measures are taken at repeated time intervals described below.
Time frame: 0 min to 240 min
Change from Baseline Blood Hormonal Satiety Markers
Glucagon-like peptide-1 (GLP-1), Peptide tyrosine-tyrosine (YY), Ghrelin, Leptin, Gastric Inhibitory Peptide (GIP), Peptide C
Time frame: 0 min to 240 min
Amount of food consumed in a "food ad libitum"
240 min After eating the study product
Time frame: 240 min
Total amount of food consumed in 24h
24h Food Record Method
Time frame: 24 hours
Change from Baseline Glucose Metabolism Parameters
Concentration of Glucose
Time frame: 0 min to 240 min
Anthropometric Parameters
Weight and height will be combined to report BMI in kg/m2
Time frame: 24 hours
Adverse Effects
Number of participants with gastrointestinal symptoms (Nausea, Diarrhea, Bloating and other disorders)
Time frame: 24 hours
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