The objective of this trial is to evaluate the effects of setria performance blend supplementation on endurance performance in healthy men.
This study is a randomized, double-blind, placebo-controlled crossover trial in healthy men. Subjects will take either a placebo or setria performance blend (L-citrulline + glutathione) for 8 days. At the day 8, subjects run on the treadmill to measure the time to exhaustion at 90%, 100%, and 110% of peak velocity. Arterial blood flow and blood vessel diameter (via ultrasound), blood analytes (plasma nitrate/nitrite, L-arginine, L-citrulline), subjective feelings of fatigue from a visual analog scale (VAS) and ratings of perceived exertion will be assessed. There is a minimum of a two week washout period in between trials/treatments. The same procedures are completed upon return visit.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
25
Oral capsules
Oral capsules
Applied Physiology Laboratory, Fetzer Hall Room 25
Chapel Hill, North Carolina, United States
Change in Time to exhaustion (sec)
Measured from a treadmill run before and after 8 days of supplementation
Time frame: 8 days
Change in Blood Flow (ml/min-1)
Measured from ultrasound before and after 8 days of supplementation
Time frame: 8 days
Change in Vessel Diameter (mm)
Measured from ultrasound before and after 8 days of supplementation
Time frame: 8 days
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