Identifying modifiable factors that contribute to preeclampsia risk associated with assisted reproduction can improve maternal health. Recent studies have shown an increased risk for hypertensive disorders of pregnancy after in vitro fertilization, particularly for pregnancies occurring during a hormone replacement therapy such a donor egg recipient and a frozen embryo transfer. This risk may be partly attributable to the degree by which the assisted reproductive treatment affects the maternal hormonal environment, when the corpus luteum is a major source of reproductive hormones. On the other hand, cryopreserved embryos are usually thawed and replaced in in a natural or hormonally manipulated cycle; on this point, frozen embryo transfer is associated with better perinatal outcome regarding preterm birth and low birth weight yet higher risk of large for gestational age and macrosomia compared to fresh transfer. The objective of our study is to investigate whether the absence of corpus luteum adversely affects pregnancy and to analyse if there are differences in the perinatal outcomes due to differences in the endometrial preparation protocol for a frozen embryo transfer.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
591
The intervention group will be prepared with hormone replacement therapy with estrogens according to usual clinical practice. Frozen embryos will be transferred after ten doses of exogenous progesterone.
Ivi Valencia
Valencia, Spain
Incidence of pre-eclampsia during pregnancy.
Presence or absence of pre-eclampsia during pregnancy
Time frame: 12 months
Bleeding during pregnancy
Presence or absence of Bleeding during pregnancy
Time frame: 12 months
Hypertension during pregnancy
Presence or absence of Hypertension during pregnancy
Time frame: 12 months
Eclampsia during pregnancy
Presence or absence of Eclampsia during pregnancy
Time frame: 12 months
Preeclampsia during pregnancy
Presence or absence of Preeclampsia during pregnancy
Time frame: 12 months
Retarded intrauterine growth during pregnancy
Presence or absence of retarded intrauterine growth at birth
Time frame: 12 months
Premature detachment of normoinserted placenta during pregnancy
Presence or absence of premature detachment of normoinserted placenta during pregnancy
Time frame: 12 months
Type II Diabetes during pregnancy
Presence or absence of Type II Diabetes during pregnancy
Time frame: 12 months
Help Sindrome during pregnancy
Presence or absence of Help Sindrome during pregnancy
Time frame: 12 months
Alterations in the volume of the amniotic fluid during pregnancy
Presence or absence of alterations in the volume of the amniotic fluid during pregnancy
Time frame: 12 months
Preterm premature rupture of membranes during pregnancy.
Presence or absence of preterm premature rupture of membranes during pregnancy
Time frame: 12 months
Fetal death
Presence or absence of fetal death at birth.
Time frame: 12 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.