A Study Evaluating the Efficacy and Safety on Moderate to Severe Dry Eye

Inclusion Criteria 1. Have a history of use eye drops for dry eye symptoms within 6 months of Visit 1 or desire to use eye drops; 2. Have in the study eye a Schirmer's Test score of ≤ 10 mm and ≥ 1 mm at Visits 1 and 2; 3. Be willing and can adjust current treatment for dry eye according to the protocol, judged by the Investigator; 4. Must be willing to complete all study assessments required by the protocol. Exclusion Criteria: 1. Be diagnosed with an ongoing ocular infection (bacterial, viral, or fungal), or active ocular inflammation at Visit 1; 2. Have previously had laser-assisted in situ keratomileusis (LASIK) surgery within the last 12 months, or had femtosecond small incision lenticule extraction (SMILE) within the last 12 months, or had phacoemulsification within the last 3 months, or had dry eye or aggravation of dry eye caused by other ocular operations has not been stable; 3. Have used ophthalmic cyclosporine A, tacrolimus or Xiidra® within 60 days prior to Visit 1;