The purpose of this study is to assess the effect of standard usual care combined with daily supervised physical training during hospitalization with community-acquired pneumonia (CAP) compared to standard usual care alnone.
Community-acuired pneumonia (CAP) is a leading cause of hospitalization worldwide. Despite increased focus on mobilization, hospitalization is associated with bed rest. Bed rest with low levels of physical activity leads to functional deline as well as increased risk of complications. This study is a randomized controlled trial, which investigates the effect of standard usual care combined with daily supervised physical training in patients hospitalized with CAP compared to standard usual care alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
210
Patients will daily perform 30 min of supervised in-bed cycling
Patients will daily perform 30 min of supervised physical training with exercises from the exercise booklet
Department of Pulmonary and Infectious Diseases, Nordsjællands Hospital
Hillerød, Denmark
RECRUITINGLength of hospital stay
Number of stays in hospital
Time frame: From admission until discharge (an average of 5 days)
Readmissions Number of readmissions
Time-to-event within 3-months from discharge
Time frame: 3-months from discharge
Mortality
Time-to-event within 6-months from discharge
Time frame: 6-months from discharge
Changes in total lean mass
Dual-energy x-ray absorptiometry scans
Time frame: Day 1, day 5, discharge, 1- and 3-months from discharge
Changes in total fat mass
Dual-energy x-ray absorptiometry scans
Time frame: Day 1, day 5, discharge, 1- and 3-months from discharge
Changes in total fat-free mass
Bioelectrical impedance analysis
Time frame: Day 1, day 5, discharge, 1- and 3-months from discharge
Health-related quality of life
Scoring from -0.624 to 1.000 on the 5-level EQ-5D version (EQ-5D-5L) questionnaire (Danish version), with higher score indicating better health-related quality of life
Time frame: Day 1, discharge, 1-, 3- and 6-months from discharge
Activities of daily living
Scoring from 0 to 100 on the Barthel Index for Activities of Daily Living (ADL) with higher score indicating greater independence.
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Time frame: Day 1, discharge, 1 month from discharge and 3 months from discharge
Muscle strength
Hand grip strength test
Time frame: At day 1, day 5, discharge, 1- and 3-months after discharge
Functional ability
30-sec chair stand test
Time frame: Day 1, day 5, discharge, 1- and 3-months after discharge
Systemic inflammation
Pro- and anti-inflammatory cytokine concentrations measured in pg/ml (IL-6, IL-8, IL-18, IL-1a, IL-10, TNF-alpha)
Time frame: Daily during admission (day 0 to 5), 1- and 3-months after discharge
Physical activity monitoring
AX3 accelerometers
Time frame: During admission (up to 7 days), 7 days from discharge, 7 days from 1- and 3 months follow-up