The link between epigenetic changes as an effect of psychotherapy has been investigated recently. Genes investigated in these studies were brain-derived neurotrophic factor (BDNF), NR3C1, FKBP51, MAOA and GLUT1. Change in methylation of these genes could be a biomolecular mechanism of psychotherapy induced changes. This study project aims at providing evidence for a biological mechanism of personality disorder interventions in adolescence by investigating the link between epigenetic changes as an effect of psychotherapy. It investigates the correlation between changes in the methylation of the FKBP5 gene and psychotherapy induced changes in symptoms and functioning.
Study Type
OBSERVATIONAL
Routine psychotherapy as treatment for patients with Borderline Personality Disorder
change in methylation of the FKBP5 gene
change in methylation of the FKBP5 gene
Time frame: after 6 months from baseline
change in methylation of the FKBP5 gene
change in methylation of the FKBP5 gene
Time frame: at month 3 and at month 12 after baseline.
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