The Effect of Epidural Anesthesia on the Optic Nerve Sheath Diameter in Preeclampsia

Seoul National University Hospital22 enrolled

Overview

This study aims to assess the effect of epidural anesthesia on the optic nerve sheath diameter in parturients with preeclampsia.

This prospective observational study will be performed in parturients, either with or without preeclampsia, who scheduled to undergo elective cesarean delivery under epidural anesthesia. Epidural anesthesia will be done according to the standard technique. Optic nerve sheath diameter (ONSD) will be measured before and after the epidural injection of anesthetic solutions using ultrasonography. The investigators will assess whether epidural anesthesia has effect on optic nerve sheath diameter of pregnant women, and the investigators will also compare ONSD between healthy parturients and parturients with preeclampsia. The investigators will evaluate the relationship between ONSD and disease severity of preeclampsia.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Preeclampsia

Interventions

Epidural anesthesiaPROCEDURE

Epidural anesthesia using standardized technique

Eligibility

Sex: FEMALEMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled to undergo planned cesarean section under epidural anesthesia if they have a singleton pregnancy, complicated by severe preeclampsia. Severe preeclampsia was defined using the American College of Obstetricians and Gynecologist Task Force on Hypertension in Pregnancy recommendations * Controls will be healthy pregnant women at term (\>37 weeks), with a singleton pregnancy, no signs or symptoms of preeclampsia and no intrauterine fetal growth restriction, who are planned to undergo elective cesarean delivery under epidural anesthesia Exclusion Criteria: * Contraindication to epidural anesthesia * Morbid cardiovascular disease * Cerebrovascular disease * Known fetal anomaly * Any signs of onset of labor * Body weight \< 40 kg or body weight \> 100 kg * Height \< 140cm or height \> 190cm * eye disease * infection or trauma near the eyes * abnormality of intracranial pressure due to Intracranial pathology

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Optic nerve sheath diameter (ONSD) after epidural anesthesia

measured by transocular ultrasonography

Time frame: 3 minutes after the completion of epidural injection of the anesthetic solutions

Secondary Outcomes

Optic nerve sheath diameter (ONSD)

measured by transocular ultrasonography

Time frame: before epidural anesthesia, 10, 20 minutes after the completion of epidural injection of the anesthetic solutions, 10 minutes after delivery of fetus, at the end of surgery.

Blood pressure

blood pressure in mmHg

Time frame: on delivery day

Proteinuria

The presence of Proteinuria during the admission period