Thyroid associated ophthalmopathy (TAO) is a common autoimmune disorder. The pathogenesis of TAO is unclear, and studies found that T cell, B cell and monocytes, macrophages and mast cells are located in the orbital tissue of TAO. Dysthyroid optic neuropathy (DON) is the most serious complication of TAO, which can cause blurred vision, color vision and vision function damage, and affects the quality of life. Investigation of the therapeutic effect of orbital decompression may provide some clues to make the policy at treatment of DON. We explore the therapeutic effect of orbital decompression in patients with DON in both eyes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
20
Orbital decompression combined with MPT
Zhongshan Opthalmic Center
Guangdong, Guangdong, China
RECRUITINGBCVA
best corrected visual acuity in logMAR
Time frame: 6 months
IOP
intraocular pressure in mmHg
Time frame: 6 months
proptosis
proptosis in mm
Time frame: 6 months
upper eyelid retraction
upper eyelid retraction in mm
Time frame: 6 months
CAS
clinical activity score
Time frame: 6 months
MD
mean deviation of visual field in dB
Time frame: 6 months
PSD
pattern standard deviation of visual field in dB
Time frame: 6 months
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