Senofilcon A Lenses in Moderate to Severe Dry Eye Disease

Inclusion Criteria: * Confirmed diagnosis of moderate to severe dry eye associated with either Graft-versus-host disease (GVHD), Sjogren syndrome, idiopathic dry eyes, or minimal limbal cell deficiency * A baseline Schirmer tear test (1) of less than 5 mm at 5 minutes without anesthesia * Have a visual analog score for comfort of 50 or less (scale of 1-100, with 100 meaning perfect ocular comfort and 1 meaning severe ocular pain) * Ability or the resources to insert and remove the study lenses * An OSDI score greater than 42 * A willingness to sign an informed consent Exclusion Criteria: * No dry eyes or mild dry eyes * A baseline Schirmer tear test (1) of greater than 5 mm of wetting at 5 minutes * Dry eye comfort score of greater than 50 on a visual analog scale * Unable to insert or remove the study lenses (or have a family member do so) * Have an OSDI score less than 42 * Has been diagnosed with neurotrophic keratopathy in either eye * Unwilling to enroll in the study, and unwilling to provide signed informed consent to participate in the study