This is an initial pilot study to test feasibility, participant engagement and satisfaction, and clinical and neurobiological target engagement of a behavioral treatment called "ASCEND" that combines computer-based cognitive training and coaching of cognitive strategies to improve daily cognitive functioning in individuals with stroke.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
3
ASCEND is a behavioral intervention that combines computer-based cognitive exercise, strategy coaching with a neuropsychologist, and homework exercises in order to improve attention, working memory, and cognitive control after stroke.
NewYork-Presbyterian Hospital/Weill Cornell Medical Center
New York, New York, United States
Participant satisfaction with ASCEND, as measured by the Client Satisfaction Questionnaire-8 (CSQ-8)
The CSQ-8 is a self-report measure of participant satisfaction with the intervention. Scores range from 8-32 with higher scores indicating greater satisfaction.
Time frame: 5 weeks (at the conclusion of treatment)
Participant impression of ASCEND as a credible treatment to improve cognition, as measured by the Credibility and Expectancy Questionnaire (CEQ).
The CEQ is a self-report measure that assesses participants' perceived benefit and improvement from the intervention. Each item is scored on a 1-9 Likert-type scale or as a percentage rating from 0% to 100% in 10% increments.
Time frame: 5 weeks (at the conclusion of treatment)
Change in auditory attention and working memory, as measured by the Digit Span test
Performance-based measure of attention/working memory with scores ranging from 0-48, with higher scores indicating better performance.
Time frame: Baseline, 5 weeks
Change in visual attention and working memory, as measured by the Symbol Span test
Performance-based measure of attention/working memory with scores ranging from 0-50, with higher scores indicating better performance.
Time frame: Baseline, 5 weeks
Change in divided attention and working memory, as measured by the Symbol-Digit Modalities Test
Performance-based measure of divided attention/working memory with scores ranging from 0-120, with higher scores indicating better performance.
Time frame: Baseline, 5 weeks
Change in divided attention and processing speed, as measured by the Trail Making Test
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Performance-based and timed measure of divided attention/processing speed with lower scores indicating better performance (faster completion time).
Time frame: Baseline, 5 weeks
Change in selective attention and inhibitory control, as measured by the Stroop Test
Performance-based and timed measure of selective attention and inhibition, with higher scores indicating better performance.
Time frame: Baseline, 5 weeks
Change in rapid working memory and mental arithmetic, as measured by the Paced Auditory Serial Addition Test (PASAT)
Performance-based and timed measure of rapid working memory, with higher scores indicating better performance.
Time frame: Baseline, 5 weeks
Change in attention and working memory as measured by the Mental Control test
Performance-based measure of simple auditory attention and working memory. Scores range from 0-12 with higher scores indicating better performance.
Time frame: Baseline, 5 weeks
Change in executive functioning as measured by the Weekly Calendar Planning Activity
Performance-based measure of executive functioning. Higher scores indicate better performance.
Time frame: Baseline, 5 weeks
Change in self-reported executive functioning as measured by the Behavior Rating Inventory of Executive Function-Adult
Self-report measure of executive functioning. Higher scores indicate greater problems with executive dysfunction in daily life.
Time frame: Baseline, 5 weeks
Change in self-reported cognitive symptoms due to stroke, as measured by the Patient Reported Evaluation of Cognitive State (PRECIS).
Self-report measure of cognitive difficulties after stroke. Scores range from 0-128 with higher scores indicating greater cognitive problems in daily life due to stroke.
Time frame: Baseline, 5 weeks