This study will characterize patients with ischemic stroke, a condition which occurs when a vessel supplying blood to the brain is obstructed, and a subpopulation of patients with irregular and often rapid heart rate (atrial fibrillation) in a UK general population using The Health Improvement Network (THIN) database. The main aim of the study is to estimate in how many patients atrial fibrillation was diagnosed at the moment of stroke and to describe whether these patients received OAC at the time of the stroke. In addition, researchers want to learn about the relative risk of ischemic stroke when such patients did not continue OAC treatment.
The primary objectives of the study are to determine the incidence of ischemic stroke in patients registered in the British primary care THIN database and to investigate the OAC exposure, OAC treatment patterns and the relative risk of having an ischemic stroke in relation to OAC treatment for a subgroup of patients, who were diagnosed with non-valvular atrial fibrillation (NVAF) prior to ischemic stroke. Secondary objectives are to determine the number of patients having NVAF diagnosed at the time of ischemic stroke and within 1 and 12 months after ischemic stroke; to describe cardiovascular risk factors for ischemic stroke and pharmacological treatments before and 12 months after ischemic stroke, and to estimate the case-fatality at 1 and 12 months after the occurrence of ischemic stroke.
Study Type
OBSERVATIONAL
Enrollment
3,739
Oral anticoagulants may comprise vitamin K antagonists (VKA) and non-vitamin K antagonist oral antagonists (NOAC).
Many facilities
Multiple Locations, United Kingdom
Number of subjects with ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2018
Incidence of ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2018
Number of NVAF patients with OAC prescription prior to ischemic stroke
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Duration of OAC treatment before OAC discontinuation for NVAF patients
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Time period from OAC discontinuation to ischemic stroke for NVAF patients
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke after OAC discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke by time since OAC discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke by OAC treatment duration before OAC discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke after VKA discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke by time since VKA discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke by VKA treatment duration before VKA discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke after NOAC discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke by time since NOAC discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Relative risk of NVAF patients for ischemic stroke by NOAC treatment duration before NOAC discontinuation
For NVAF subgroup only
Time frame: Retrospective analysis of data from 01-Jul-1996 to 30-Jun-2018
Number of subjects with first diagnosis of NVAF at time of ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2018
Number of subjects with first diagnosis of NVAF within 1 month after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jul-2018
Number of subjects with first diagnosis of NVAF within 12 months after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Prevalence of cardiovascular co-morbidities one year before ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Prevalence of cardiovascular co-morbidities 12 months after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Descriptive analysis of pharmacological treatments of patients with known NVAF diagnosis within 12 months before ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Descriptive analysis of pharmacological treatments of patients with known NVAF diagnosis within 12 months after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Descriptive analysis of pharmacological treatments of patients without known NVAF diagnosis within 12 months before ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Descriptive analysis of pharmacological treatments of patients without known NVAF diagnosis within 12 months after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Case-fatality of patients with known NVAF diagnosis at 1 month after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Case-fatality for patients with known NVAF diagnosis at 12 months after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Case-fatality of patients with unknown NVAF diagnosis at 1 month after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019
Case-fatality of patients with unknown NVAF diagnosis at 12 months after ischemic stroke
Time frame: Retrospective analysis of data from 01-Jul-2016 to 30-Jun-2019