There are many factors that can affect the diagnostic yield of EUS-FNA, including lesion factors, the endoscoist experience, the needle size, the number of needle passes, and the suction technique. since diagnostic efficacy of different suction techniques for EUS-FNB is still uncertain, thus we decided to compare the diagnostic efficacy of three common methods: the 10 ml standard negative pressure, slow pull and wet suction.
the standard suction: after the needle is inserted in the mass, removing the stylet before performing EUS-FNA. Then attach a 10mL syringe to the end of needle. 20 times of for-backward Suction was applied after the lesion was punctured. slow-pull : after the needle is inserted in the mass, slowly pull the stylet out while performing EUS-FNA with 20 times for-backward. wet suction: after removing the stylet, the needle was flushed with 5mL of saline solution to replace the column of air with saline. A 10mL syringe was attached to the end of the needle. 20 times of for-backward Suction was applied after the lesion was punctured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
300
After the needle is inserted in the mass, removing the stylet before performing EUS-FNA. Then attach a 10mL syringe to the end of needle. 20 times of for-backward Suction was applied after the lesion was punctured.
After the needle is inserted in the mass, slowly pull the stylet out while performing EUS-FNA with 20 times for-backward.
After removing the stylet, the needle was flushed with 5mL of saline solution to replace the column of air with saline. A 10mL syringe was attached to the end of the needle. 20 times of for-backward Suction was applied after the lesion was punctured.
Changhai Hospital, Second Military Medical University
Shanghai, China
RECRUITINGdiagnostic accuracy of each individual technique
The results are compared with the gold standard and calculated the accuracy
Time frame: 1 year
diagnostic sensitivity of each individual technique
The results are compared with the gold standard and calculated the sensitivity
Time frame: 1 year
specificity of each individual technique
The results are compared with the gold standard and calculated the specificity
Time frame: 1 year
adverse event rate of each individual technique
record any adverse events related to the procedure
Time frame: 1 year
adequacy of specimens obtained by each individual technique
the adequacy will be determined by the pathologists analyzing the sample using a pre-defined scale. They will be blinded to the technique used
Time frame: 1 year
cellularity
the cellularity will be determined by the pathologists analyzing the sample using a pre-defined scale. They will be blinded to the technique used
Time frame: 1 year
blood contamination
the blood contamination will be determined by the pathologists analyzing the sample using a pre-defined scale. They will be blinded to the technique used
Time frame: 1 year
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