Clinical Trial to Assess the Efficacy of µSmin® Plus

Inclusion Criteria: * Male or female with age ≥18 and ≤60 with chronic venous insufficiency; * The chronic venous insufficiency must be graded between C2-C4 on the Clinical-Etiology-Anatomy-Pathophysiology (CEAP) classification system; * Able to communicate adequately with the investigator and to comply with the requirements for the entire study; * Capable of and freely willing to provide written informed consent prior to participating in the study; * Light smokers (\<10 cigarettes per day). Exclusion Criteria: * Patients suffering from other or associated vascular diseases, diabetes or bleeding disorders; * Oedema of the lower limbs of cardiac, renal or hepatic origin; * Presence of symptoms and/or trophic disorders of arterial, metabolic, neurological or orthopedic origin including traumas, arthritis, neuropathy; * One or more factors likely to affect venous symptoms such as recent childbirth, recent stripping, or deep or superficial venous thrombosis of the lower limbs during the previous 6 months; * Obese subjects (BMI \> 30); * Hypersensitivity to active principles contained in the tested food supplement (diosmin); * Patients considered smokers (≥10 cigarettes/day); * Patients with concomitant or history of addiction to alcohol, spices or drug abuse; * Pregnant women, nursing mothers, or women (only if childbearing potential) not using adequate methods of contraception; * Participation in an interventional clinical study in the previous 30 days; * Presence of any clinically significant medical condition judged by the investigator to preclude the patient's inclusion in the study.