25 to 50% of endometriotic patients are infertile and use medically assisted procreation. In general, the assessment of pain in medically assisted procreation is very little studied. Pain assessment studies in endometriotic patients remain limited to a quantitative assessment of pain symptomatology, without contextualization of painful manifestations. The primary objective of our study is the qualitative and contextualized assessment of pain during In Vitro Fertilization (IVF) protocol in endometriotic and non-endometriotic patients. The secondary objectives of our study are the quantitative study of pain, the measurement of the impact of personal efficiency on painful symptomatology, evaluation of depression, the results of IVF (implantation, pregnancy and live birth rates), and compare pain between endometriotic or non-endometriotic patients and between primary infertility and secondary infertility. According to the results obtained in this study, therapeutic strategies for the management of pain could be proposed, with the aim of improving the quality of life and the results of IVF in these patients.
Study Type
OBSERVATIONAL
Enrollment
318
Survey will be at different time of the IVF protocol (at the first medical appointment in the medically assisted department, after stimulation, after oocytes retrieval, after embryo transfer, one month after the IVF protocol)
Hop Jeanne de Flandre Chu Lille
Lille, France
Comparison of the scores obtained by the pain survey (EN, QDSA, DN4), quality of life survey (EQ-5D), depression and anxiety (HAD), pain catastrophism score (PCS) and assessment of personal efficacy (heiQ).
composite criteria to assess of the typology of pain
Time frame: one month after the IVF protocol
EN = numerical scale of pain
from 0 to 10 (0 is "no pain" and 10 is "maximum pain imaginable")
Time frame: one month after the IVF protocol
Questionnaire douleur Saint Antoine (QDSA)
QDSA for emotional and sensory dimension of pain. It's a word list to describe a pain, patient must specify the type of pain that she usually feels for 8 days by putting a cross for the correct answer (0 to 4: absent, weak, moderate, strong, extremely strong)
Time frame: one month after the IVF protocol
DN4
emotional and sensory dimension of pain, neuropathic pain survey in four questions - score on 7
Time frame: one month after the IVF protocol
EQ-5D quality of life
overall score on a numeric scale "check the box that best describes your health today", 5 themes (mobility, autonomy of the person, common activities, pain / discomfort, anxiety / depression)
Time frame: one month after the IVF protocol
HAD,anxiety and depression
2 scores on 21 - "circle the number that best fits your condition"
Time frame: one month after the IVF protocol
pain catastrophism scale (PCS)
score between 0 to 52
Time frame: one month after the IVF protocol
heiQ = personal efficiency,
40 questions with 8 dimensions
Time frame: one month after the IVF protocol
Comparison of the scores obtained by the pain survey (EN, QDSA, DN4), quality of life survey (EQ-5D), depression and anxiety (HAD), pain catastrophism score (PCS) and assessment of personal efficacy (heiQ).
composite criteria to assess of the typology of pain
Time frame: at Baseline (the first medical appointment) and 15 days after the embryo transfer
implantation rates (%)
measure in endometriotic and non-endometriotic patients,in primary and secondary infertility patients
Time frame: at Baseline (the first medical appointment), 15 days after embryo transfer, and at one month of the IVF cycle
pregnancy rate (%)
measure in endometriotic and non-endometriotic patients,in primary and secondary infertility patients
Time frame: at Baseline (the first medical appointment), 15 days after embryo transfer, and at one month of the IVF cycle
live birth rate (0 or 1)
measure in endometriotic and non-endometriotic patients,in primary and secondary infertility patients
Time frame: at Baseline (the first medical appointment), 15 days after embryo transfer, and at one month of the IVF cycle
renouncing a new IVF attempt: yes or no
measure the impact of pain on the pregnancy project in endometriotic and non-endometriotic patients,in primary and secondary infertility patients
Time frame: at Baseline (the first medical appointment), 15 days after embryo transfer, and at one month of the IVF cycle
willingness to take a specific treatment with an analgesic goal: yes or no answer
measure the impact of pain on the pregnancy project in endometriotic and non-endometriotic patients,in primary and secondary infertility patients
Time frame: at Baseline (the first medical appointment), 15 days after embryo transfer, and at one month of the IVF cycle
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