The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
60
Effect of High Intensity Interval Training compared to Hydrochlorothiazide on ambulatory Blood Pressure.
Cardiovascular Prevention and Rehabilitation Center
Montreal, Quebec, Canada
RECRUITING24h-Ambulatory Blood Pressure
The 24-hour ambulatory measure of the blood pressure (AMBP)
Time frame: At baseline and after twelve weeks of intervention
Cardiovascular evaluation
Maximum incremental cardiopulmonary exercise test (VO2MAX)
Time frame: Before and after twelve weeks of intervention
Cognitive functions
Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. The investigators will measure change of score to the cognitive tests.
Time frame: Before and after twelve weeks of intervention
Flow Mediated Dilatation (FMD)
Percentage of dilatation of the brachial artery
Time frame: Before and after twelve weeks of intervention
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