Mitochondrial Remodeling After Exercise

Oregon State University31 enrolled

Overview

Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Overweight and Obesity Insulin Resistance Metabolic Disease Mitochondrial Metabolism Sedentary Lifestyle

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-45 years * Body mass index (BMI) 18-45 kg/m2 * Sedentary (\<1 hour of planned exercise per week) Exclusion Criteria: * Regular exercise (\>1 hour of planned exercise per week) * Smoking, tobacco or nicotine use within the last 1-year * Fasting glucose \>126mg/dL * Hypertension (systolic pressure \>140 mmHg or diastolic pressure \>90 mmHg) * Chronic metabolic or cardiovascular health conditions * Pregnant, nursing, irregular menses or post-menopausal * Lidocaine allergy * Certain medications * Physical limitations that prevent safe or successful exercise completion * Diminished capacity for consent

Outcomes

Primary Outcomes

Change in skeletal muscle mitochondrial protein degradation peptide products

Skeletal muscle mitochondrial protein degradation peptide products after 2-weeks of exercise training compared with before training.

Time frame: After 2-weeks of exercise training compared with before training.