Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant

Inclusion Criteria: * Patients eligible for inclusion in this study have to fulfill all of the following criteria: 1. A signed informed consent prior to patient participation in the study and before any assessment is performed. 2. Patients who are able to take oral medication. 3. 18 years old 4. Undergoing first OLT 5. Dialysis for 45 days or less at time of transplant 6. Able and willing to conform to requirements of the study 7. Able and willing to provide informed consent Exclusion Criteria: <!-- --> 1. \< 18 years old 2. Autoimmune liver disease, Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis 3. Dialysis greater than 45 days 4. Receiving ATG, IVIG therapy, or sirolimus/everolimus around time of transplant or sirolimus/everolimus after transplant 5. Unable to take oral medications 6. Participating in another clinical research study involving the evaluation of another investigational drug or device 7. Documented allergy to basiliximab, TAC, MMF or any macrolide antibiotic. 8. Presence of thrombosis of any major hepatic arteries 9. Complex/high risk arterial reconstruction at any time (graft vessel patency by Doppler ultrasound confirmed and documented). 10. Patients who are recipients of multiple solid organ transplants, (e.g., multivisceral or combined liver-kidney transplants), or have previously received an organ or tissue transplanted, or who received an ABO incompatible transplant. 11. Patients who have severe hypercholesterolemia (\>215 mg/dL; \>5.5 mmol/L) or hypertriglyceridemia (\>265 mg/dL; \>3.0 mmol/L) at Baseline. 12. Patients who have severe thrombocytopenia or neutropenia (platelet count \>20 and MLCs\>1000) 13. Patients who have any surgical or medical condition, which in the opinion of the investigator, might significantly alter the absorption, distribution, metabolism and excretion of study drugs 14. Patients with a known hypersensitivity to the drugs used on study or their class, or to any of the excipients. 15. Patients with clinically significant systemic infection 16. Pregnant or nursing (lactating) female patients, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive βHCG laboratory test (\>9 mIU/mL) at Baseline.