The study included 176 patients with COPD. The first group included 88 normal weight patients with COPD: 71 men and 17 women, mean age 62.40 ± 8.83 years. The second group included 88 patients with COPD and obesity: 64 men and 24 women, mean age 62.94 ± 5.96 years. We assessed the frequency of COPD exacerbations in last 12 months, the severity of symptoms such as dyspnea, sputum production, fatigue. Spirometry, six-minute walk test and analysis of body tissue type composition were performed. BODE index was calculated. Levels of leptin, adiponectin, interleukins-4,6,8,10, interferon-γ, c-reactive protein (CRP), tumor necrosis factor receptor 1 (TNF-R1), tumor necrosis factor receptor 2 (TNF-R2), tumor necrosis factor alpha (TNF-α) were measured in blood serum.
Study Type
OBSERVATIONAL
Enrollment
176
Voronezh State Medical University
Voronezh, Russia
Simptoms
dyspnea, sputum production and fatigue
Time frame: 1 year
Labotary tests
Levels of interleukins-4,6,8,10, interferon-γ, tumor necrosis factor receptor 1 (TNF-R1), tumor necrosis factor receptor 2 (TNF-R2), tumor necrosis factor alpha (TNF-α) were measured in blood serum (pg / ml)
Time frame: 1 year
Spirometry
FEV1, % pred,FVC, % pred.,FEV1/FVC, %
Time frame: 1 year
Labotary tests
Levels of leptin (ng / ml) measured in blood serum
Time frame: 1 year
Labotary tests
Levels of adiponectin (µg / ml) measured in blood serum
Time frame: 1 year
Symptroms and laboratory correlations
Statistical methods allowing to figure out associations and correlations between blood tests and symptoms
Time frame: 1 year
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