Electroencephalogram (EEG) in General Anaesthesia - More Than Only a Bispectral Index (BIS)

University Hospital, Basel, Switzerland232 enrolled

Overview

Processed electroencephalogram (EEG) monitors are routinely used in addition to clinical parameters to assess the depth of anaesthesia during general anaesthesia.

Processed electroencephalogram (EEG) monitors are routinely used in addition to clinical parameters to assess the depth of anaesthesia during general anaesthesia. In addition to the bispectral (BIS) index displayed as an index, the raw frontal EEG can be displayed as a curve on these monitors. After a short training, anaesthetists might be more accurate and faster in assessing depth of anaesthesia by recognizing the pattern of the EEG curve than by using the BIS index. This may further enhance the positive effects that could be demonstrated for the use of BIS monitors. Therefore, the aim of the investigator's study is to investigate the clinical relevance of interpreting the raw frontal EEG in addition to only using the BIS index for titrating intravenous anaesthetics.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

232

Conditions

Anesthesia

Interventions

Training for EEG monitoringOTHER

Training for reading EEG curves during anaesthesia

Standard monitoringOTHER

Standard monitoring including clinical parameters and BIS index

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients undergoing in-hospital laparoscopic abdominal surgery with general anaesthesia using Propofol based on the Schnider model (target controlled infusion)42, 43 * Minimal duration of surgery of 60 minutes * Written informed consent Exclusion Criteria: * Same-day surgery * Language barrier * Patients under 18 years of age * Pregnancy (using a beta-human chorionic gonadotropin (HCG) measurement in a blood sample of women in childbearing age) * Allergy to Propofol * Administration of hypnotics other than Propofol, such as ketamine or midazolam preoperatively or intraoperatively * Known brain pathology, such as seizure disorders, dementia, cerebrovascular disease or brain death

Locations (4)

Cantonal Hospital Aarau

Aarau, Switzerland

University Hospital Basel

Basel, Switzerland

Cantonal Hospital Graubünden

Chur, Switzerland

Clinic of Anaesthesiology

Geneva, Switzerland

Outcomes

Primary Outcomes

Quality of recovery (QoR): QoR-15 scale

QoR-15 scale (scale from 0 to 150; 0 means best, 150 worst recovery)

Time frame: 24 hours after surgery

Secondary Outcomes

Propofol consumption

Propofol consumption in mg/kg/h

Time frame: during anaesthesia

Quality of recovery (QoR): QoR-15 scale

QoR-15 scale (scale from 0 to 150; 0 means best, 150 worst recovery)

Time frame: 48 hours after surgery

Time spent in postanaesthesia care unit (PACU)

Time in minutes from arrival in PACU until discharge from PACU

Time frame: At arrival to and at discharge from postanaesthesia care unit (an average of 120 minutes)

Time to extubation

Time in minutes from skin closure to extubation

Time frame: At time of skin closure and at time of extubation (an average of 90 minutes)

Risk of awareness

Brice interview daily until hospital discharge

Time frame: daily from admission up to hospital discharge, an average of approximately 14 days

Aldrete score

Measurement of recovery; score is 0 to 10, 0 means worst recovery, 10 means best recovery

Time frame: Once at discharge from postanaesthesia care unit (PACU), approximately on day 2 of admission to hospital

Incidence of Postoperative Nausea and Vomiting (PONV)

Data from ClinicalTrials.gov

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