Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease

Survival

Survival rate at 12 months

Time frame: at 12 months

Change in serum total bilirubin

Total bilirubin is a liver parameter, used for the biological liver test evaluation, measured in mg/dl in the serum

Time frame: Baseline, at 7 days, at 30 days, at 3 months at 6 months and at 12 months

Change in serum creatinine

Creatinine is a marker of kidney function, assessed in the blood and measured in milligrams per deciliter

Time frame: Baseline, at 7 days, at 30 days, at 3 months at 6 months and at 12 months

Change in MELD (Model for End-stage Liver Disease)score

The MELD score is a validated tool based on INR, creatinine and bilirubin measured in the blood with the following formula:(9.57 × log creatinine in milligrams per deciliter) + (3.78 × log bilirubin in milligrams per deciliter) + (11.20 × log international normalized ratio) + 6.43. The MELD score is used in liver disorders to assess the degree of liver failure. It has no unit.

Time frame: Baseline, at 7 days, at 30 days, at 3 months at 6 months and at 12 months

Identification of inflammatory and biochemical profiles of patients with severe, non-severe and cirrhotic alcoholic hepatitis, based on the constitution of a biobank (serum and plasma)

Serum and plasma evaluation of translational markers (e.g. cytokines) associated with inflammation in patients with alcohol-related liver disease. The list of markers which will be assessed cannot be determined at present and will depend on other ongoing studies performed in alcoholic hepatitis.

Time frame: Baseline, at 7 days, at 30 days and at 12 months

Identification of the genetic profiles of individuals with severe, non-severe and cirrhotic alcoholic hepatitis( blood sample)

Evaluation of genetic markers associated with alcoholic hepatitis as compared to patients with alcohol-related liver disease without alcoholic hepatitis. We will use a non a priori approach as recommended in genetic studies. Thus, the list of genetic markers cannot be provided at that time.

Time frame: Baseline

Measurement of diagnostic performance (area under the ROC curve)

Measurement of diagnostic performance (area under the ROC curve) of the simple and non-invasive clinical and biological criteria for alcoholic hepatitis proposed in an international expert opinion

Time frame: At baseline