A Study of OV101 in Individuals With Angelman Syndrome (AS)

Inclusion Criteria: * Male or female and 2 to 12 years old (inclusive) at the time of informed consent * Confirmed molecular diagnosis of AS * Has a CGI-S-AS score of 3 or more at baseline. * Meets the following age-appropriate body weight criterion: 1. Subjects 2 to 3 years old must have a minimum body weight of 9 kg. 2. Subjects 4 years and older must be between 17 kg and 64 kg (inclusive). * Stable concomitant mediations for at least 4 weeks before study start Exclusion Criteria: * Any condition that would limit study participation * Clinically significant lab or vital sign abnormalities at the time of screening * Poorly controlled seizures (weekly seizures of any frequency with a duration more than 3 minutes, weekly seizures occurring more than 3 times per week, each with a duration of less than 3 minutes, or as defined by investigator assessment) * Use of prescription medications for sleep, minocycline, or levodopa within the 4 weeks prior to Day 1 or during the study. Benzodiazepines chronically administered for seizure control are permitted. * Cannot comply with protocol study assessments during screening or caregiver unable to comply with study requirements. * Enrolled in any clinical trial or used any investigational agent within the 30 days before screening or concurrently with this study.