Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

Beijing Chao Yang Hospital30 enrolled

Overview

To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

End Stage Liver DIsease Liver Transplantation

Interventions

fresh frozen plasmaBIOLOGICAL

perform plasma transfusion in different phases during perioperation

blood sampleDIAGNOSTIC_TEST

get blood samples at several specific points in time during perioperation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Child A/B cirrhosis * patients who undergo the first OLT * Informed and consented * complete follow-up * cooperate with treatment Exclusion Criteria: * re-transplant * combined liver and other organ transplantation * BMI≥30Kg/m2 * patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion * acute liver failure

Locations (1)

Capital Medical University Affiliated Beijing Chaoyang Hospital

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

endothelial glycocalyx layer shedding markers

plasma concentration of endothelial glycocalyx layer shedding markers

Time frame: 24 hours

Secondary Outcomes

inflammatory cytokines

levels of inflammatory cytokines

Time frame: 24 hours

Central Contacts

Xun Liu

CONTACT

+86 13466505725 13466505725@163.com

Anshi Wu

CONTACT

+86 010 85231330 wuanshi@hotmail.com

Data from ClinicalTrials.gov

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