The objective of this pilot study is to collect preliminary data using total body scans on a new, first of its kind, FDA 510k-cleared positron emission tomography/computed tomography (PET/CT) scanner, called EXPLORER.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
Intervention: PET/CT using different protocols
University of California, Davis
Sacramento, California, United States
Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM
To collect preliminary data regarding FDG biodistribution in the organs listed as a function of time of 12 hours. Time-activity curves will be created
Time frame: approximatively 12 hours for Arm 1 only
Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value)
To obtain preliminary data regarding low dose EXPLORER noise level
Time frame: approximatively 6 hours for Arm 1 only
Standardized Uptake Value
To collect preliminary data about total body FDG perfusion and early biodistribution. Time-activity curves will be created
Time frame: approximatively 90 minutes
Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM
To obtain preliminary data to understand whether intravenous iodinated contrast agent produce a significant change in quantification of FDG uptake levels. Time/activity curves will be generated.
Time frame: approximatively 3 hours
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