Safety, Tolerability, and Pharmacokinetics of HSK21542 in Healthy Volunteers

Inclusion Criteria: * Healthy male and female subjects, age 18-45 years; * BMI between 18.0-27.0 kg/m2 * Determined by investigator to be in general good health according to medical history, comprehensive physical examination; * Understanding of the nature, significance, potential benefits and risks of the trial, understanding of the procedures and be able to provide written informed consent voluntarily ; * Good communication with investigators, compliance with the study requirements and willingness to stay in phase I clinical trial ward as required. Exclusion Criteria: * Anyone who has suffered or is currently suffering from any serious diseases, that may interfere with the results of the trial; * Determined by investigator to be abnormal with clinical significance in Physical examination, vital signs monitoring, electrocardiogram, chest radiograph, laboratory examination; * HBsAg positive, HCV antibody positive, Treponema pallidum antibody positive, or HIV antibody positive; * QTcF \> 450ms; * Allergic constitution; * Intolerance of venipuncture and/or history of haemorrhage or needle fainting; * Drug or alcohol abuse; * Have used any prescription, over-the-counter, Chinese herbal medicine or health products within 14 days; * Blood donation or massive bleeding within 3 months (greater than 450 mL); * Participants in any drug clinical trial within 3 months. * Birth planning in the next six months.