Preoperative Excercise Training for Patients Undergoing Coronary Artery Bypass Graft Surgery

Kerckhoff Klinik203 enrolled

Overview

Patients (pts) with stable coronary artery disease (CAD) requiring coronary artery bypass graft surgery (CABG) may be physically inactive during the waiting period to avoid further risks. Aim of this study is to investigate the feasibility and safety of a preoperative aerobic exercise training in these pts during the waiting period and to analyze its effects on pre-, peri and postoperative outcomes

Pts with stable coronary artery disease (CAD) and indication for elective CABG will be prospectively randomized into a preoperative training group (TG) or a non active control group (CG). Pts in TG have to perform six sessions of aerobic endurance training within two weeks prior to CABG. The following investigations will be performed at baseline, one day before surgery and at the beginning and at the end of cardiac rehabilitation: a maximal symptom limited ergospirometry, assessment of endothelial function (analysing the reactive hyperaemic index (RHI) via a finger-tonometry), assessment of quality of life (QoL) using the MacNew Heart Disease Questionnaire, laboratory testing of ischemic and inflammatory Parameters. Baseline, peri- and postoperative characteristics will be collected.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

203

Conditions

Coronary Artery Disease Physical Activity Coronary Artery Bypass Graft Surgery

Interventions

Preoperative Exercise TrainingOTHER

Patients undergoing CABG and randomized to the Training Group complete six sessions of aerobic endurance training prior CABG surgery

Optimal medical therapyOTHER

Standard medication for stable CAD

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * stable Angina * indication for elective CABG surgery * functional capacity \> 50 watts * willingness to participate in the study Exclusion Criteria: * unstable Angina * comorbidities precluding performance of aerobic exercise training (e.g. neurological disorders, orthopedic disorders etc) * functional Status NYHA IV * relevant ventricular arrhythmias * hemodynamic significant heart valve disease * myocarditis * cardiomyopathies * left main coronary artery disease \> 50% * peripheral obstructive disease (Fontaine \> IIb) * reduced life expectancy \< 12 months * CABG surgery during the last six months * participation in another trial

Locations (1)

Kerckhoff Klinik

Bad Nauheim, Germany

Outcomes

Primary Outcomes

Cardiopulmonary fitness

Change of maximal Oxygen consumption

Time frame: Baseline, prior surgery on hospital admission day, hospital discharge day ( postoperative day 7-14) , after 3 weeks of cardiac rehabilitation

Endothelial function

Change of Reactive hyperemic index (RHI)

Time frame: Baseline, prior surgery on hospital admission day, hospital discharge day (postoperative day 7-14), after 3 weeks of cardiac rehabilitation

Secondary Outcomes

Length of hospital stay (LoS)

Duration of hospital stay in days

Time frame: Within the acute care period

Length of ventilation

Duration of Ventilation in minutes

Time frame: Within the acute care period

Functional capacity

Change of 6-minute walk test