Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock

Inclusion Criteria: * Patients\> 18 years of age with diagnosis of septic shock and multiorgan failure admitted to our Unit * Entry into the ICU once diagnosed with sepsis and / or septic shock. The first 24 hours after admission to the ICU will be established as an inclusion limit * Written informed consent. Exclusion Criteria: * Patients under 18 * Pregnancy * Coexistence of other types of shock at admission * Limitation of therapeutic effort or ICT (Conditional Intensive Therapy) upon admission to the ICU. It refers to patients in whom, prior to admission to the ICU, it was decided not to perform any or some of the usual treatment measures for sepsis, or in which a time limit is established in which in case of non-response they would withdraw intensive measures. This limitation will be indicated by your treating physician and if it exists, the patient would be excluded from the study. * Patient with a history of previous intake of ascorbic acid, thiamine or corticosteroids in the month prior to admission to the ICU * Patients considered immunodeficient (More than 10 mg of prednisone or its equivalent per day in the last 2 weeks, immunosuppressive therapy or diagnosis of acquired immunodeficiency syndrome).