The aim of the "HEALING" " (Hospital-based Ecumenical And Linguistic Immuno-NeuroloGic) Study was to examine immunological and neurological changes in hospitalized participants after meeting a chaplain and Biblical listenings, in order to evaluate whether these meetings affect the course of the disease.
The authors pre-screened hospitalized participants to find those who were the most in need of an intervention by a chaplain. A passage from the Bible was read to the participants during a meeting with the chaplain at the bedside, or in the chapel of the hospital. No meeting occurred in the randomized control group, which was compiled in a way to get a group of participants with an approximatively similar pattern of diagnoses and treatment days than the intervention groups. The pace of enrollment was deliberately slow in order to assure the authenticity of the visits ("slow science"). Blood samples were taken 30 minutes prior, and 60 minutes after the meeting to measure White Blood Cell (WBC)-, lymphocyte counts, interferon gamma (IFN-γ)-, immunoglobulin M (IgM)-, immunoglobulin A (IgA)-, immunoglobulin G (IgG)-, and complement C3 levels. A subgroup of the visited participants was subjected to functional Magnetic Resonance Imaging (fMRI), where they were played an audiotape of readings of the same passage from the Bible. Associative tests, paired-samples t-test, network analysis was performed to search for any correlation between psychological and immunological parameters, completed with Statistical Parametric Mapping to search for correlations of the above with neurological parameters.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
57
Somogy Megyei Kaposi Mór Teaching Hospital
Kaposvár, Hungary
Change in lymphocyte count
lymphocyte count measured with automatised laboratory measurement and microscopic blood smear examination
Time frame: Change from baseline at 120 minutes
Change in total white blood cell (WBC) count
WBC count measured with automatised laboratory measurement and microscopic blood smear examination
Time frame: Change from baseline at 120 minutes
Change in interferon-gamma level
enzyme-linked immunosorbent assay
Time frame: Change from baseline at 120 minutes
Change in immunoglobulin M level
enzyme-linked immunosorbent assay
Time frame: Change from baseline at 120 minutes
Change in immunoglobulin A level
enzyme-linked immunosorbent assay
Time frame: Change from baseline at 120 minutes
Change in immunoglobulin G level
enzyme-linked immunosorbent assay
Time frame: Change from baseline at 120 minutes
Change in complement C3 level
enzyme-linked immunosorbent assay
Time frame: Change from baseline at 120 minutes
Change in functional Magnetic Resonance Imaging activity
Statistical Parametric Mapping analysis of Blood Oxygenation Level Dependent (BOLD) answers
Time frame: Change from baseline during the 60 second long activation block
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Participants' satisfaction with the visit as assessed by Scores given on the "Healing - after" Questionnaire
Participants' assessement of their satisfaction on single-item rating scales in a Questionnaire designed for the Study. Answers range from 1 to 5, with higher values representing better outcomes.
Time frame: within 1 hour after intervention
Chaplain's satisfaction with the visit as assessed by Scores given on the "Healing - after" Questionnaire
Chaplain's assessement of her satisfaction on single-item rating scales in a Questionnaire designed for the Study. Answers range from 1 to 5, with higher values representing better outcomes.
Time frame: within 1 hour after intervention
Participants' level of distress in the month preceding the measurement as assessed with the total Score of the Perceived Stress Scale 14 (PSS-14)
PSS-14 Scale uses 14 questions with answers ranging from 0 to 4, with higher values indicating higher levels of distress on the seven negative-, and lower levels of distress on the seven positive items. Scores are obtained by reversing the scores on the seven positive items, then summing across all to give the total PSS-14 Score.
Time frame: within 30 minutes before intervention
Participants' spiritual and psychological needs, religious practice, thoughts about how they became sick, and how they could heal, as assessed by Scores given on the "Healing - before" Questionnaire
Participants' assessement on single-item rating scales in a Questionnaire designed for the Study ("Healing - before" Questionnaire). Answers range from 1 to 5, with higher values representing better outcomes.
Time frame: within 30 minutes before intervention