Pulmonary Vascular Disease and Cardiac Performance in Extreme Preterm Infants

McGill University Health Centre/Research Institute of the McGill University Health Centre150 enrolled

Overview

Pulmonary vascular disease and cardiac performance in extreme preterm infants: A prospective cross-sectional study

The principal investigator hypothesize that premature newborns have disturbed cardiac performance and increased pulmonary pressures during neonatal life and at different pediatric ages. The principal investigator also hypothesize that premature newborns with poor cardiac performance and/or pulmonary hypertension have higher morbidities and poorer neuro-developmental outcomes. The principal investigator also hypothesize that premature newborns with poor cardiac performance and/or pulmonary hypertension have higher morbidities and poorer neuro-developmental outcomes and that novel echocardiography techniques will detect anomalies not uncovered by conventional imaging, and that early echocardiography may identify those with later pulmonary hypertension.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Prematurity; Extreme

Interventions

EchocardiographyOTHER

Diagnostic test which uses ultrasound waves to make images of the heart chambers, valves and surrounding structures

Eligibility

Sex: ALLMin age: 7 DaysMax age: 5 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infants born at \<29 weeks' gestational age admitted to the NICU * All infants born at \<29 weeks' gestational age followed at MCH clinic after an admission in the NICU for prematurity \<29 weeks Exclusion Criteria: * Congenital heart disease (except an atrial (ASD) or ventricular septal defect (VSD), or a patent ductus arteriosus (PDA)) * Congenital severe lung or airway malformation (choanal atresia, trachea-esophageal fistula or congenital pulmonary airway malformation) * Genetic disorder (Trisomy 21).

Locations (1)

Mcgill University Health Centre

Montreal, Quebec, Canada

RECRUITING