Contributing Factors to Anterior Resection Syndrome and Its Impact on Quality of Life: A Retrospective Cohort Study

University of Malta179 enrolled

Overview

This study adds to the understanding of the contributing factors leading to LARS, the long term effects of this syndrome post-operatively and its impact on quality of life.

Study Type

OBSERVATIONAL

Enrollment

179

Conditions

Low Anterior Resection Syndrome Cancer Quality of Life

Interventions

anterior resectionPROCEDURE

The distance from anal verge, preoperative radiotherapy and presence of stoma were analysed

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All adult patients \>18 years, under the care of all surgical firms at Mater Dei Hospital, who had undergone anterior resection for rectal cancer between January 2014 and December 2016 Exclusion Criteria: * colorectal cancer (\>15cm) from anal verge * permanent stoma * known disseminated or recurrent disease, * patient without restitution of bowel continuity after 1 year

Locations (1)

Mater Dei Hospital

Valletta, Malta

Outcomes

Primary Outcomes

LARS incidence

Incidence of LARS in patients who had anterior resection

Time frame: 1 year

Risk factors

Variable factors which might have contributed to LARS were the following: * Age * Gender * Diabetes mellitus * Pathological stage * MRI stage * Distance from anal verge * Surgical technique * Preoperative radiotherapy * Preoperative chemotherapy * Postoperative radio/chemotherapy * Type of anastomosis * Presence of stoma * Interval from stoma reversal * Duration of follow-up

Time frame: 1 year

Life

The association between LARS and quality of life was assessed.

Time frame: 1 year

Data from ClinicalTrials.gov

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