GCF IL-17 Levels and Oxidative Status of Smoking and Non-smoking Individuals With Periodontitis

Ondokuz Mayıs University30 enrolled

Overview

This study was performed to evaluate the effects of both periodontal treatment and smoking on the gingival crevicular fluid(GCF) levels of interleukin (IL)-17A, IL-17E, Total oxidative stress(TOS) and total antioxidant capasity(TAOC) in smoking and non-smoking patients with severe chronic periodontitis. Systemically healthy 15 smoker,15 non-smoker with chronic periodontitis were attended for the study. Periodontal status were determined by recording periodontal clinical measurements. GCF samples were collected at the baseline, at the end of initial periodontal treatment and 4 weeks after periodontal flap surgery. The data were tested statistically by the Student t and paired sample t tests.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Periodontitis Smoking, Cigarette

Eligibility

Sex: ALLMin age: 35 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * individuals aged ˃35 years and having ≥16 teeth diagnosed as chronic periodontitis * not received any periodontal therapy within the previous 6 months; * not received antibiotic/anti-inflammatory drug treatment within the previous 6 months. Exclusion Criteria: * receiving medical treatment for cancer, rheumatoid arthritis, diabetes mellitus, cardiovascular disease, or any other systemic disease; * being pregnant or being in the period of menopause or lactation; * receiving any drug therapy that might affect the clinical characteristics of periodontitis; * usage of systemic antimicrobials during the 6 weeks prior to data collection

Outcomes

Primary Outcomes

GCF IL-17A VOLUME

IL-17A is a cytokine present in gingival crevicular fluid. Its volume calculated as microliter and changes due to inflammation caused by periodontal disease.

Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .

GCF IL-17E VOLUME

IL-17E is a cytokine present in gingival crevicular fluid. Its volume calculated as microliter and changes due to inflammation caused by periodontal disease.

Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .

GCF TOTAL OXIDATIVE STRESS (TOS) LEVEL

TOS is the measurement of oxidative stress amount and given as mmol/L unit. Its amount changes due to inflammation caused by periodontal disease.

Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .

GCF TOTAL ANTIOXIDANT CAPASITY (TAOC)

TAOC is the antioxidant amount measured and given as μmol H2O2 Eq/L unit. Its amount changes due to inflammation caused by periodontal disease.

Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .

GCF IL-17 Levels and Oxidative Status of Smoking and Non-smoking Individuals With Periodontitis

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes