SIB in Upper Thoracic Esophageal Squamous Cell Carcinoma

Inclusion Criteria: 1. Histological or cytologic diagnosis of esophageal squamous carcinoma; 2. Aged 18-75 years; 3. KPS ≥ 70; 4. Upper thoracic esophageal squamous carcinoma: the upper margin of the lesion is located between the entrance of esophagus and the inferior edge of the azygos vein; 5. Stage I-IVA(AJCC 6th,2009); 6. Not able to be surgically resection or rejected; 7. Not have received any prior anticancer therapy; 8. No serious system dysfunction and immuno-deficiency, Adequate organ function including the following: Hemoglobin ≥9 g/dL, WBC≥4x109/L, Neutrophils (ANC )≥1.5x10\^9/L, platelet count ≥100x 10\^9/L, serum creatinine\<1.5 mg/dL,urea nitrogen \<8 mmol/L; 9. No history of malignancy; 10. No perforation of esophagus, no deep ulcer of esophagus; 11. Joined the study voluntarily and signed informed consent form. Exclusion Criteria: 1. Pregnant or breast-feeding women or people during the birth-period who refused to take contraceptives; 2. Patient who has metastasis such as lung, liver metastasis; 3. Other malignant tumors; 4. Uncontrolled seizures or psychiatric diseases, loss of control over their own behavior; 5. Uncontrollable heart disease, diabetes and hypertension, pulmonary fibrosis, and chest confirmed active pulmonary inflammation require antibiotic treatment, as well as superior vena cava compression syndrome; 6. After surgery, exploratory thoracotomy, radiotherapy, chemotherapy, or targeting therapy; 7. Combination of pure red cell anemia or gamma globulin; 8. Allergic to any medication component studied.