An expanding number of studies suggest a therapeutic role for nitrate and nitrite, most notably in treatment and prevention of cardiovascular disease including ischemia-reperfusion injury and hypertension. The nutritional aspects of these cardioprotective effects are particularly intriguing since nitrate is abundant in our everyday diet. Nitrate improves vascular functions in old adults and improves ischemia reperfusion injury in experimental models. Whether dietary nitrate improves erectile dysfunction is not known and will be investigated in the present study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
40
Oral dietary nitrate supplementation with (0,12 mmol/kgBW sodium-nitrate)
Placebo Comparator: Dietary sodium-chloride dissolved in water (0,12 mmol sodium-chloride/kgBW/day)
University Hospital Essen
Essen, North Rhine-Westphalia, Germany
RECRUITINGThe changes of erectile function according to the international index of erectile function (IIEF5) score
Erectile dysfunction improvement as measured by IIEF5 score (range 5-25)
Time frame: 4 Weeks
Change in oral microbiome
Change in oral microbiome after dietary nitrate ingestion
Time frame: 4 Weeks
Change in cardiac diastolic function,
Change in cardiac diastolic function as determined by echocardiography via measurement of E/A and E/e' aggregated to display diastolic function
Time frame: 4 weeks
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