An Open-label, Single-center, Parallel-group Study to Assess Pharmacokinetics, Safety, and Tolerability of a Single Dose of MT-7117 in Subjects with Normal and Impaired Hepatic Function
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
23
Single Dose of MT-7117
University of Miami Clinical Pharmacology Unit
Miami, Florida, United States
Maximum observed plasma concentration (Cmax) of MT-7117
Time frame: 0-96 Hours
Area under the plasma concentration time curve from time zero to the time of last quantifiable concentration (AUC0-last) of MT-7117
Time frame: 0-96 Hours
Area under the plasma concentration time curve from time zero to infinity (AUC0-∞) of MT-7117
Time frame: 0-96 Hours
Time to reach maximum plasma concentration (tmax) of MT-7117
Time frame: 0-96 Hours
Plasma terminal elimination half-life (t1/2) of MT-7117
Time frame: 0-96 Hours
Apparent oral clearance (CL/F) of MT-7117
Time frame: 0-96 Hours
Apparent volume of distribution (Vz/F) of MT-7117
Time frame: 0-96 Hours
fraction of unbound drug in plasma or serum (fu) of MT-7117
Time frame: 0-96 Hours
Number of participants with Adverse events (AEs) and Serious Adverse Events (SAEs)
Time frame: 0-96 Hours
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