The central hypothesis is that daily dental xylitol wipes, in addition to current oral care practice, are effective at reducing BSI from oral organisms, and decreasing the incidence of gingivitis, oral plaque, and oral ulcerations after SCT.
Our long-term goal is to develop and disseminate clinically relevant, and easily adoptable strategies to prevent BSI and improve outcomes after SCT. The overall objective of this proposal is to identify a clinically effective strategy to prevent or reduce BSI secondary to bacterial translocation through oral injured mucosa .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
46
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Incidence of bacteremia in the first 30 days post-HSCT with oral organisms
Time frame: 30 days
Incidence of bacteremia in the first 30 days post-HSCT with any organism
Time frame: 30 days
Incidence of dental plaque
Time frame: 30 days
Incidence of gingival inflammation
Time frame: 30 days
Incidence of mucosal ulceration
Time frame: 30 days
Incidence of oral mucositis
Time frame: 30 days
Incidence of oral microbiome diversity
Time frame: 30 days
Incidence of oral pathogenic bacteria burden
Time frame: 30 days
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