The aim of this study is to investigate the association between the severity and duration of intraoperative hypotension and the incidence of perioperative stroke after non-cardiac and non-neurologic surgeries.The secondary aim of this study is to confirm the potential risk factors of the perioperative stroke.
Optimized intraoperative management may play an important role in perioperative stroke prevention. Maintaining blood pressure near preoperative baseline values may help decrease the incidence of stroke, however the related evidence is limited.Therefore, this study is to investigate the association between intraoperative hemodynamic variable and the risk of perioperative stroke after non-cardiac and non-neurologic surgeries. The secondary aim of this study is to establish the potential risk factors of the perioperative stroke.
Study Type
OBSERVATIONAL
Enrollment
70,000
In this study, we will use four previously defined thresholds for intraoperative hypotension: two absolute thresholds (MAP less than 50 mmHg and MAP less than 60 mmHg) and two relative thresholds to the baseline MAP (a decrease of 30% or more and a decrease of 40% or more). A definition of baseline value most frequently reported was the arterial blood pressure before the induction of anesthesia. Therefore, the baseline MAP used in calculating the relative thresholds is defined as the mean MAP of all available blood pressure measurements before induction of anesthesia in the operating room.
The First affiliated hospital of Shandong First Medical University
Jinan, Shandong, China
RECRUITINGIncidence of perioperative stroke
Perioperative stroke diagnosed with CT or MRI examination, symptoms and signs
Time frame: Within 24 hours after surgery
Incidence of perioperative stroke
Perioperative stroke diagnosed with CT or MRI examination, symptoms and signs
Time frame: Within 3 days after surgery
Incidence of perioperative stroke
Perioperative stroke diagnosed with CT or MRI examination, symptoms and signs
Time frame: Within 7 days after surgery
Incidence of perioperative stroke
Perioperative stroke diagnosed with CT or MRI examination, symptoms and signs
Time frame: Within 30 days after surgery
Rate of death
Death from any cause
Time frame: Within 24 hours after surgery
Rate of death
Death from any cause
Time frame: Within 3 days after surgery
Rate of death
Death from any cause
Time frame: Within 7 days after surgery
Rate of death
Death from any cause
Time frame: Within 30 days after surgery
Expense of Healthe care and social service
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The expense of Healthe care and social service that the patients spent in hospital
Time frame: Through study completion, an average of 14 days