Short-term Sugary Beverage Consumption on Glucose Control and Cardiovascular Disease Risk Factors

Kansas State University37 enrolled

Overview

Our goal is to determine how the addition of sugar-sweetened beverages to the diet affects glucose control, cardiovascular disease risk factors, and pulmonary function in healthy, young adults.

In a 3-arm randomized controlled trial, 36 participants consumed one of three beverages for three weeks: water (W), caffeine-free soda (S), or 100% fruit juice (FJ). Participants consumed two servings/day (\~710mL) of their randomized beverage for three weeks, along with their habitual diets. At baseline and following the 3-week intervention, participants completed glucose control, cardiovascular disease risk factor, and pulmonary function assessments.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Metabolic Syndrome

Interventions

Sugary beverage: Fruit juiceDIETARY_SUPPLEMENT

Participants consumed 100% fruit juice (\~710mL) daily for three weeks, along with their habitual diets.

Sugary beverage: SodaDIETARY_SUPPLEMENT

Participants consumed soda (\~710mL) daily for three weeks, along with their habitual diets.

Control: WaterDIETARY_SUPPLEMENT

Participants consumed water (\~710mL) daily for three weeks, along with their habitual diets.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Free from diagnosis of diabetes and pulmonary illness * Have no intake of glucose or lipid lowering medication. Exclusion Criteria: * Smoke * Currently pregnant * Have bronchitis * Have more than 2 risk factors for cardiovascular disease, as defined by the American College of Sports Medicine (ACSM).

Locations (1)

Lafene Health Center

Manhattan, Kansas, United States

Outcomes

Primary Outcomes

Change in glucose iAUC

Glucose obtained from blood sample in a fasted state and in response to a meal

Time frame: Week 0 and Week 3

Secondary Outcomes

Change in plasma lipids

Total cholesterol (TC), LDL-c , VLDL-c, HDL-c , triglycerides (TG) from blood sample in a fasted state and following consumption of a meal

Time frame: Week 0 and Week 3

Change in homeostatic model assessment for insulin resistance

Calculated from fasting glucose and insulin values

Time frame: Week 0 and Week 3

Change in blood pressure

Evaluated via automated sphygmomanometer.

Time frame: Week 0 and Week 3

Change in BMI

Weight and height will be combined to report BMI in kg/m\^2

Time frame: Week 0 and Week 3

Change in pulmonary function

Assessed using the maximum flow-volume loop

Time frame: Week 0 and Week 3

Change in insulin iAUC

Glucose obtained from blood sample in a fasted state and in response to a meal

Time frame: Week 0 and Week 3

Change in serum fructosamine

Fructosamine obtained from blood sample

Time frame: Week 0 and Week 3

Data from ClinicalTrials.gov

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