Autonomic Regulation in Prader-Willi Syndrome

Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation120 enrolled

Overview

To evaluate autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.

To evaluate the relationship between narcolepsy and sleep-disordered breathing, the natural course of untreated or treated sleep-disordered breathing and its impacts on autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Autonomic Dysfunction

Interventions

PolysomnographyDIAGNOSTIC_TEST

overnight polysomnography recording at least six hours

Multiple sleep latency testDIAGNOSTIC_TEST

daytime naps at least four to five naps to evaluate daytime sleepiness and narcolepsy

Continuous positive airway pressureOTHER

continuous positive airway pressure treatment for sleep-disordered breathing

Eligibility

Sex: ALLMin age: 7 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 7-75 y/o Prader-Willi syndrome patients or healthy subjects * can perform polysomnography, multiple sleep latency test * orthostatic methods for autonomic function test * can perform pulmonary function test. Exclusion Criteria: * less than y/o, or larger then 75 y/o * cannot perform polysomnography, multiple sleep latency test * cannot orthostatic methods for autonomic function test * cannot perform pulmonary function test * use of sedatives or drugs affecting autonomic function

Locations (1)

Taipei Tzu-Chi Hospital, Buddhist Tzu-Chi Medical Foundation

New Taipei City, Taiwan

RECRUITING

Outcomes

Primary Outcomes

Narcolepsy prevalence

Compare the narcolepsy prevalence amount healthy and Prader-Willi syndrome with or without sleep-disordered breathing

Time frame: 1day

Secondary Outcomes

The natural course and its impact of untreated sleep-disordered breathing on autonomic regulation in patients with Prader-Willi syndrome.

Autonomic function measurements (low frequency power and high frequency power, presented as normalized units, and the overall autonomic regulation presented as Low frequency/high frequency ratio) using the EKG signal extracting from overnight polysomnography recording raw data among Prader-Willi patients with untreated sleep-disordered breathing at baseline and after a period of follow-up.

Time frame: 12 months

Central Contacts

美貞楊, MD

CONTACT

0970333784 mimimai3461@gmail.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.